Biological Activity
Selective neuromedin B receptor (NMB-R, BB1) antagonist (Ki values are 216 and 18,264 nM for BB1 and BB2 receptors respectively). Displays no activity at a range of other receptors.
Technical Data
| M. Wt | 1192.46 |
| Formula | C63H73N11O9S2 |
| Sequence |
XCYWKVCX (Modifications: Disulfide bridge between 2 - 7, X-1 = D-Nal, Trp-4 = D-Trp, X-8 = Nal & C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 111857-96-6 |
| PubChem ID | 16173213 |
| InChI Key | WASLGBPOQJKRMS-AAFDAGAGSA-N |
| Smiles | [H]N[C@H](CC1=CC2=CC=CC=C2C=C1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC1=O)C(C)C)C(=O)N[C@H](CC1=CC2=CC=CC=C2C=C1)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in 0.1% acetic acid |
Preparing Stock Solutions
The following data is based on the product molecular weight 1192.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.84 mL | 4.19 mL | 8.39 mL |
| 5 mM | 0.17 mL | 0.84 mL | 1.68 mL |
| 10 mM | 0.08 mL | 0.42 mL | 0.84 mL |
| 50 mM | 0.02 mL | 0.08 mL | 0.17 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Orbuch et al (1993) Discovery of a novel class of neuromedin B receptor antagonists, substituted somatostatin analogues. Mol.Pharmacol. 44 841 PMID: 7901752
Ryan et al (1996) Pharmacological profiles of two bombesin analogues in cells transfected with human neuromedin B receptors. Eur.J.Pharmacol. 306 307 PMID: 8813645
Milusheva et al (1998) Role of different bombesin receptor subtypes mediating contractile activity in cat upper gastrointestinal tract. Peptides 19 549 PMID: 9533644
Keywords: BIM 23042, supplier, Selective, neuromedin, B, receptor, antagonists, NMB-R, BB1, NMB-Preferring, Neuromedin, B-Preferring, Bombesin, BIM23042, Bombesin, Receptors, Bombesin, Receptors, Tocris Bioscience
