Biological Activity
Somatostatin receptor ligand (Ki values are 142, > 1000, 10.8, 16.6 and 5.7 nM for human cloned sst1 - 5 receptors respectively). Behaves as an antagonist on SRIF14-induced [35S]-GTPγS binding at sst3 and sst5 receptors (PKB values are 6.33 and 5.84 respectively).
Technical Data
| M. Wt | 1232.49 |
| Formula | C71H81N11O9 |
| Sequence |
FFYWKVFX (Modifications: Phe-1 = D-Phe, Trp-4 = D-Trp, X = D-Nal & C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 150155-61-6 |
| PubChem ID | 16133799 |
| InChI Key | VPTPBEUWKCLZGU-OOSWLFMASA-N |
| Smiles | [H]N[C@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@H](CC1=CC2=CC=CC=C2C=C1)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in 20% acetonitrile / water |
Preparing Stock Solutions
The following data is based on the product molecular weight 1232.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.81 mL | 4.06 mL | 8.11 mL |
| 5 mM | 0.16 mL | 0.81 mL | 1.62 mL |
| 10 mM | 0.08 mL | 0.41 mL | 0.81 mL |
| 50 mM | 0.02 mL | 0.08 mL | 0.16 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Patel and Srikant (1994) Subtype selectivity of peptide analogs for all five cloned human somatostatin receptors (hsstr 1-5). Endocrinology 135 2814 PMID: 7988476
Raynor et al (1993) Cloned somatostatin receptors: identification of subtype-selective peptides and demonstration of high affinity binding of linear peptides. Mol.Pharmacol. 43 838 PMID: 8100350
Siehler and Hoyer (1999) Characterisation of human recombinant somatostatin receptors. Modulation of GTPgammaS binding. Naunyn Schmiedebergs Arch.Pharmacol. 360 500 PMID: 10598789
Wilkinson et al (1996) Potent antagonism by BIM-23056 at the human recombinant somatostatin sst5 receptor. Br.J.Pharmacol. 118 445 PMID: 8762063
Keywords: BIM 23056, supplier, Somatostatin, receptor, agonists, Receptors, BIM23056, Somatostatin, Receptors, Somatostatin, Receptors, Tocris Bioscience
