BiologicalActivity
Potentandselective,ATP-competitiveglycogensynthasekinase-3(GSK-3)inhibitor(IC50valuesare5,83,300,320and>10000nMatGSK-3,CDK5/p25,CDK2/cyclinA,CDK1/cyclinBandothercommonkinasesrespectively).Maintainsself-renewalandpluripotencyinembryonicstemcellsviaactivationoftheWntsignalingpathwayinvitro;alsopromotesproliferationanddedifferentiationincardiomyocytes.Negativecontrolavailable(Cat.No.3873).
CompoundLibraries
BIOisalsoofferedaspartoftheTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 356.17 |
| Formula | C16H10BrN3O2 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 667463-62-9 |
| PubChemID | 5287844 |
| InChIKey | WNWSUJQVZJJGLF-SQFISAMPSA-N |
| Smiles | O/N=C(C1=CC=CC=C1N2)/C2=C3/C(NC4=C3C=CC(Br)=C4)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 3.56 | 10 | |
| ethanol | 3.56 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight356.17.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.81mL | 14.04mL | 28.08mL |
| 5mM | 0.56mL | 2.81mL | 5.62mL |
| 10mM | 0.28mL | 1.4mL | 2.81mL |
| 50mM | 0.06mL | 0.28mL | 0.56mL |
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ProductDatasheets
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