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Tocris Bioscience(优势品牌)
主营:主营:分子类,蛋白类,抗体类,生化类试剂
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当前位置: 首页 > 产品中心 > Other_reagents > Tocris/BIO 5192/5051/10/10 mg
商品详细Tocris/BIO 5192/5051/10/10 mg
Tocris/BIO 5192/5051/10/10 mg
Tocris/BIO 5192/5051/10/10 mg
商品编号: 5051/10
品牌: Tocris Bioscience
市场价: ¥5100.00
美元价: 3060.00
产地: 美国(厂家直采)
公司:
产品分类: 其他试剂
公司分类: Other_reagents
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description:Highlypotentandselectiveinhibitorofintegrinα4β1
ChemicalName:(2S)-2-[[[(2S)-1-[(3,5-Dichlorophenyl)sulfonyl]-2-pyrrolidinyl]carbonyl]amino]-4-[[(2S)-4-methyl-2-[methyl[2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl]amino]-1-oxopentyl]amino]butanoicacid
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Highlyselectiveandpotentinhibitorofintegrinα4β1(VeryLateAntigen-4;VLA-4)(Kd<10pM).Selectivelybindsα4β1overarangeofotherintegrins(IC50valuesare1.8,138,1053,>500and>10,000nMforα4β1,α9β1,α2β1,α4β7andαIIbβ3,respectively).Inducesa30-foldincreaseinmobilizationofmurinehematopoieticstemandProgenitorcells;displaysa3-foldadditiveeffectwithAMD3100(Cat.No.3299).

CompoundLibraries

BIO5192isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt817.78
FormulaC38H46Cl2N6O8S
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber327613-57-0
PubChemID10350459
InChIKeyMNQBPRHHZPXCKZ-ZDCRTTOTSA-N
SmilesO=C(NC2=CC=C(CC(N(C)[C@@H](CC(C)C)C(NCC[C@@H]([C@@](O)=O)N[C@]([C@H]3N(S(C4=CC(Cl)=CC(Cl)=C4)(=O)=O)CCC3)=O)=O)=O)C=C2)NC1=CC=CC=C1C

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
1eq.NaOH40.8950
DMSO81.78100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight817.78.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.22mL6.11mL12.23mL
5mM0.24mL1.22mL2.45mL
10mM0.12mL0.61mL1.22mL
50mM0.02mL0.12mL0.24mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet