BiologicalActivity
Highlyselectiveandpotentinhibitorofintegrinα4β1(VeryLateAntigen-4;VLA-4)(Kd<10pM).Selectivelybindsα4β1overarangeofotherintegrins(IC50valuesare1.8,138,1053,>500and>10,000nMforα4β1,α9β1,α2β1,α4β7andαIIbβ3,respectively).Inducesa30-foldincreaseinmobilizationofmurinehematopoieticstemandProgenitorcells;displaysa3-foldadditiveeffectwithAMD3100(Cat.No.3299).
CompoundLibraries
BIO5192isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 817.78 |
| Formula | C38H46Cl2N6O8S |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 327613-57-0 |
| PubChemID | 10350459 |
| InChIKey | MNQBPRHHZPXCKZ-ZDCRTTOTSA-N |
| Smiles | O=C(NC2=CC=C(CC(N(C)[C@@H](CC(C)C)C(NCC[C@@H]([C@@](O)=O)N[C@]([C@H]3N(S(C4=CC(Cl)=CC(Cl)=C4)(=O)=O)CCC3)=O)=O)=O)C=C2)NC1=CC=CC=C1C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 1eq.NaOH | 40.89 | 50 | |
| DMSO | 81.78 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight817.78.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.22mL | 6.11mL | 12.23mL |
| 5mM | 0.24mL | 1.22mL | 2.45mL |
| 10mM | 0.12mL | 0.61mL | 1.22mL |
| 50mM | 0.02mL | 0.12mL | 0.24mL |
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ProductDatasheets
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