BiologicalActivity
PotentnegativeallostericmodulatorofLFA-1(lymphocytefunction-associatedantigen-1)(Kd=26nM).BindstotheI-domainofLFA-1.ReversIBLyinhibitsLFA-1mediatedbindingofSKW3leukemiacellstoICAM-1.Inhibitssuperantigen(SEB)-inducedIL-2productionfromlymphocytesinvitroandattenuatestheSEB-inducedincreaseinIL-2plasmalevelsinamousemodelinvivo.Orallyavailable.
CompoundLibraries
BIRT377isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 442.13 |
| Formula | C18H15BrCl2N2O2 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 213211-10-0 |
| PubChemID | 9803375 |
| InChIKey | FJNJHZQMQRVZEE-GOSISDBHSA-N |
| Smiles | CN([C@@](CC3=CC=C(Br)C=C3)(C)C(N1C2=CC(Cl)=CC(Cl)=C2)=O)C1=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.21 | 100 | |
| ethanol | 22.11 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight442.13.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.26mL | 11.31mL | 22.62mL |
| 5mM | 0.45mL | 2.26mL | 4.52mL |
| 10mM | 0.23mL | 1.13mL | 2.26mL |
| 50mM | 0.05mL | 0.23mL | 0.45mL |
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ProductDatasheets
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