BiologicalActivity
GLPandG9ahistonelysinemethyltransferaseinhibitor(IC50valuesare0.7and1.7μMrespectively)thatdisplaysnoactivityatotherhistonemethyltransferasesupto37μM.ModulatesH3K9me2levelsinmammaliancellsandpotentiatesinductionofpluripotentstemcellsfromsomaticcellsinvitro.AlsoinhibitsH3K36methylationbyoncoproteinsNSD1,NSD2andNSD3(IC50valuesare40-112μM).
ExternalPortalInformation
Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofBIX-01294isreviewedonthechemicalprobeswebsite.
CompoundLibraries
BIX01294isalsoofferedaspartoftheTocriscreenPlus,TocriscreenEpigeneticsToolboxandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 600.02 |
| Formula | C28H38N6O2.3HCl |
| Storage | DesiccateatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 1392399-03-9 |
| PubChemID | 46945860 |
| InChIKey | FMURUEPQXKJIPS-UHFFFAOYSA-N |
| Smiles | CN(CCC3)CCN3C2=NC1=CC(OC)=C(OC)C=C1C(NC4CCN(CC5=CC=CC=C5)CC4)=N2.Cl.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 60 | 100 | |
| water | 60 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight600.02.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.67mL | 8.33mL | 16.67mL |
| 5mM | 0.33mL | 1.67mL | 3.33mL |
| 10mM | 0.17mL | 0.83mL | 1.67mL |
| 50mM | 0.03mL | 0.17mL | 0.33mL |
MolarityCalculator
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ProductDatasheets
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