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当前位置: 首页 > 产品中心 > Other_enzymes > Tocris/BIX 02189/4842/50/50 mg
商品详细Tocris/BIX 02189/4842/50/50 mg
Tocris/BIX 02189/4842/50/50 mg
Tocris/BIX 02189/4842/50/50 mg
商品编号: 4842/50
品牌: Tocris Bioscience
市场价: ¥16500.00
美元价: 9900.00
产地: 美国(厂家直采)
公司:
产品分类: 其它酶
公司分类: Other_enzymes
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description:SelectiveMEK5andERK5inhibitor
ChemicalName:(3Z)-3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N,N-dimethyl-2-oxo-1H-indole-6-carboxamide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

SelectiveMEK5andERK5inhibitor(IC50valuesare1.5and59nMrespectively).Inhibitssorbitol-inducedERK5phosphorylationinHeLacells.SelectiveforMEK5andERK5overMEK1/2,ERK1/2andapanelof87kinases.Inducesapoptosisinacutemyeloidleukemiatumorcells.

CompoundLibraries

BIX02189isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxII.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt440.54
FormulaC27H28N4O2
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber1265916-41-3
PubChemID46931012
InChIKeyHOMJAAIVTDVQJA-IZHYLOQSSA-N
SmilesO=C2NC1=CC(C(N(C)C)=O)=CC=C1/C2=C(C4=CC=CC=C4)/NC3=CC(CN(C)C)=CC=C3

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
1eq.HCl44.05100
DMSO44.05100
ethanol44.05100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight440.54.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.27mL11.35mL22.7mL
5mM0.45mL2.27mL4.54mL
10mM0.23mL1.13mL2.27mL
50mM0.05mL0.23mL0.45mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet