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Tocris Bioscience(优势品牌)
主营：主营：分子类，蛋白类，抗体类，生化类试剂
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当前位置： 首页 > 产品中心 > Receptors > Tocris/BMS 182874 hydrochloride/1441/10/10 mg
商品详细Tocris/BMS 182874 hydrochloride/1441/10/10 mg
Tocris/BMS 182874 hydrochloride/1441/10/10 mg
Tocris/BMS 182874 hydrochloride/1441/10/10 mg
商品编号： 1441/10
品牌： Tocris Bioscience
市场价： ¥3980.00
美元价： 2388.00
产地： 美国(厂家直采)
公司：
产品分类： 受体
公司分类： Receptors
联系Q Q： 3392242852
电话号码： 4000-520-616
电子邮箱： info@ebiomall.com
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商品介绍
Description:Highlyselective,orallyactivenon-peptideETAantagoNIST
ChemicalName:5-(Dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamidehydrochloride
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potent,selectiveandcompetitivenon-peptideendothelinETAreceptorantagonist(Ki=48nM).Displays>1000-foldselectivityoverETBreceptors.InhibitsET-1-inducedpressorresponsefollowingoralorintravenousadministrationinvivo.InhibitsET-1-inducedlongitudinalmusclecontractioninthemousecoloninvitro.

LicensingInformation

SoldwiththepermissionofBristol-MyersSquibbCompany,subjecttoU.S.PatentNo.5,378,715andotherUSandforeignpatents

CompoundLibraries

BMS182874hydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt381.88
FormulaC17H19N3O3S.HCl
StorageStoreatRT
Purity≥98%(HPLC)
CASNumber1215703-04-0
PubChemID56972163
InChIKeyUZZFRNZGYDOBAO-UHFFFAOYSA-N
SmilesCl.CN(C)C1=C2C=CC=C(C2=CC=C1)S(=O)(=O)NC1=C(C)C(C)=NO1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolubilitySolubleto100mMinDMSO

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight381.88.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.62mL13.09mL26.19mL
5mM0.52mL2.62mL5.24mL
10mM0.26mL1.31mL2.62mL
50mM0.05mL0.26mL0.52mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet