Tocris/BMS 299897/2870/10/10 mg
商品编号：
2870/10
市场价：
¥4100.00
美元价：
2460.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description:Potentγ-secretaseinhibitor
ChemicalName:2-[(1R)-1-[[(4-Chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl-5-fluorobenzeNEButanoicacid
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Orallyactive,potentγ-secretaseinhibitor(IC50=12nM).InhibitsAβ40andAβ42formationinvitro(IC50valuesare7.4and7.9nMrespectively)andreducesAβinthebrain,plasmaandcerebrospinalfluidinvivo.ExhibitsnoNotchtoxicity.Brainpenetrant.
TechnicalData
| M.Wt | 511.94 |
| Formula | C24H21ClF3NO4S |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 290315-45-6 |
| PubChemID | 11249248 |
| InChIKey | IZAOBRWCUGOKNH-OAHLLOKOSA-N |
| Smiles | FC1=CC=[C@@]([C@H](N(C3=CC(F)=CC=C3F)S(C2=CC=C(Cl)C=C2)(=O)=O)C)C(CCCC(O)=O)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 51.19 | 100 | |
| ethanol | 51.19 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight511.94.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.95mL | 9.77mL | 19.53mL |
| 5mM | 0.39mL | 1.95mL | 3.91mL |
| 10mM | 0.2mL | 0.98mL | 1.95mL |
| 50mM | 0.04mL | 0.2mL | 0.39mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet