BiologicalActivity
PotentandselectiveEGFRandErbB2inhibitor(IC50valuesare22nMand32nMrespectively).AlsoinhibitsHER4(IC50=190nM).InhibitsEGFRandErbB2with100-foldgreaterpotencythanMEKandLck.Antiproliferativeagentinvitroandanti-tumOrigenicagentinvivo.Orallybioavailable.
CompoundLibraries
BMS599626dihydrochlorideisalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxII.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 603.48 |
| Formula | C27H27FN8O3.2HCl |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| PubChemID | 90488998 |
| InChIKey | SKHKFWSXLCGMNF-IKXQUJFKSA-N |
| Smiles | FC1=CC(CN2N=CC3=C2C=CC(NC4=NC=NN5C4=C(C)C(NC(OC[C@@H]6COCCN6)=O)=C5)=C3)=CC=C1.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 60.35 | 100 | |
| water | 3.02 | 5mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight603.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.66mL | 8.29mL | 16.57mL |
| 5mM | 0.33mL | 1.66mL | 3.31mL |
| 10mM | 0.17mL | 0.83mL | 1.66mL |
| 50mM | 0.03mL | 0.17mL | 0.33mL |
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ProductDatasheets
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