Biological Activity
Highly potent and selective ETB endothelin receptor agonist (Ki values are 0.18 and 970 nM at human ETB and ETA receptors respectively).
Technical Data
| M. Wt | 2006.35 |
| Formula | C96H140N20O25S |
| Sequence |
LMDKEAVYFAHLDIIW (Modifications: Leu-1 = N-terminal Ac) |
| Storage | Desiccate at -20°C |
| CAS Number | 143113-45-5 |
| PubChem ID | 16135850 |
| InChI Key | AYJUXFCWNAVJLN-FHOIYVHLSA-N |
| Smiles | CC[C@H](C)[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(C)=O)C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 0.50 mg/ml in sodium bicarbonate (0.03M) |
Preparing Stock Solutions
The following data is based on the product molecular weight 2006.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.5 mL | 2.49 mL | 4.98 mL |
| 5 mM | 0.1 mL | 0.5 mL | 1 mL |
| 10 mM | 0.05 mL | 0.25 mL | 0.5 mL |
| 50 mM | 0.01 mL | 0.05 mL | 0.1 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Ekelund et al (1994) Effects of selective ETB-receptor stimulation on arterial, venous and capillary functions in cat skeletal muscle. Br.J.Pharmacol. 112 887 PMID: 7921617
Ihara et al (1995) [3H]-BQ-123, a highly specific and reversible radioligand for the endothelin ETA receptor subtype. Eur.J.Pharmacol. 274 1 PMID: 7768260
Reynolds et al (1995) Pharmacological differences between rat and human endothelin B receptors. Biochem.Biophys.Res.Commun. 209 506 PMID: 7733918
Sakamoto et al (1993) Distinct subdomains of human endothelin receptors determine their selectivity to endothelinA-selective antagonist and endothelinB-selective agonists. J.Biol.Chem. 268 8547 PMID: 8473300
Keywords: BQ-3020, supplier, Selective, ETB, agonists, Receptors, Endothelin, Endothelin, ETB, Receptors, Endothelin, ETB, Receptors, Tocris Bioscience
