Biological Activity
A selective h5-HT1D antagonist, displaying 60-fold selectivity over h5-HT1B, and exhibiting little or no affinity for a range of other receptor types.
Licensing Information
Sold with the permission of GlaxoSmithKline
Technical Data
| M. Wt | 443.42 |
| Formula | C25H27ClN2O.HCl |
| Storage | Desiccate at +4°C |
| CAS Number | 1173022-77-9 |
| PubChem ID | 11957475 |
| InChI Key | KQGJIKWDFWLCHO-UHFFFAOYSA-N |
| Smiles | Cl.OC(CN1CCN(CC1)C1=CC=CC(Cl)=C1)C(C1=CC=CC=C1)C1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.43 | 10 | |
| ethanol | 22.17 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 443.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.26 mL | 11.28 mL | 22.55 mL |
| 5 mM | 0.45 mL | 2.26 mL | 4.51 mL |
| 10 mM | 0.23 mL | 1.13 mL | 2.26 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.45 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Hagan et al (1997) Stimulation of 5-HT1B receptors causes hypothermia in the rat. Eur.J.Pharmacol. 331 169 PMID: 9274976
Price et al (1997) SB-216641 and BRL-15572 - compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn Schmiedebergs Arch.Pharmacol. 356 312 PMID: 9303567
Saxena et al (1998) 5-HT1-like receptors: a time to bid goodbye. TiPS 19 311 PMID: 9745358
Schlicker et al (1997) Effects of selective h5-HT1B (SB-216641) and h5-HT1D (BRL-15572) receptor ligands on guinea-pig and human 5-HT auto- and heteroreceptors. Naunyn Schmiedebergs Arch.Pharmacol. 356 321 PMID: 9303568
Keywords: BRL 15572 hydrochloride, supplier, Selective, h5-HT1D, antagonist, Serotonin, Receptors, BRL15572, hydrochloride, GlaxoSmithKline, GSK, 5-HT1D, Receptors, 5-HT1D, Receptors, Tocris Bioscience
