Biological Activity
Selective, substrate-competitive inhibitor of phosphodiesterase (PDE) 7 (Ki = 180 nM). Displays > 200-fold selectivity over PDE1B, PDE1C, PDE2, PDE3, PDE4A4 and PDE5.
Licensing Information
Sold with the permission of GlaxoSmithKline
Compound Libraries
BRL 50481 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 244.26 |
| Formula | C9H12N2O4S |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 433695-36-4 |
| PubChem ID | 2921148 |
| InChI Key | IFIUFCJFLGCQPH-UHFFFAOYSA-N |
| Smiles | CN(C)S(=O)(=O)C1=C(C)C=CC(=C1)[N+]([O-])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.43 | 100 | |
| ethanol | 24.43 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 244.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.09 mL | 20.47 mL | 40.94 mL |
| 5 mM | 0.82 mL | 4.09 mL | 8.19 mL |
| 10 mM | 0.41 mL | 2.05 mL | 4.09 mL |
| 50 mM | 0.08 mL | 0.41 mL | 0.82 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Smith et al (2004) Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: in vitro studies in human monocytes, lung macrophages, and CD8+ T-lymphocytes. Mol.Pharmacol. 66 1679 PMID: 15371556
Keywords: BRL 50481, supplier, Selective, PDE7, inhibitors, inhibits, Phosphodiesterases, BRL50481, GlaxoSmithKline, GSK, Phosphodiesterases, Phosphodiesterases, Tocris Bioscience
