Biological Activity
Selective cdk7 inhibitor (IC50 = 21 nM). Displays >40-fold selectivity for cdk7 over others cdks. Promotes cell cycle arrest and apoptosis in a range of cancer cells in vitro and inhibits MCF-7 tumor xenograft growth in mice.
Compound Libraries
BS 181 dihydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox II. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 453.45 |
| Formula | C22H32N6.2HCl |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| PubChem ID | 91826108 |
| InChI Key | XYXAMTBYYTXHSO-UHFFFAOYSA-N |
| Smiles | CC(C)C1=C2N=C(NCCCCCCN)C=C(NCC3=CC=CC=C3)N2N=C1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 45.34 | 100 | |
| ethanol | 22.67 | 50 | |
| water | 45.34 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 453.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.21 mL | 11.03 mL | 22.05 mL |
| 5 mM | 0.44 mL | 2.21 mL | 4.41 mL |
| 10 mM | 0.22 mL | 1.1 mL | 2.21 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
Molarity Calculator
Reconstitution Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Ali et al (2009) The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity. Cancer Res. 69 6208 PMID: 19638587
Keywords: BS 181 dihydrochloride, supplier, cyclin-dependent, kinase, 7, cdk7, BS-181, inhibitors, cancer, apoptosis, activating, 1397219-81-6, inhibits, Cyclin-dependent, Kinase, Cyclin-dependent, Kinase, Tocris Bioscience
