Biological Activity
A high affinity ligand for I2 imidazoline sites (Ki = 2.7 nM) with very high selectivity (> 2000-fold) over α2-adrenoceptors (Ki = 6700 nM).
Technical Data
| M. Wt | 233.7 |
| Formula | C12H11N3.HCl |
| Storage | Store at RT |
| CAS Number | 1186195-56-1 |
| PubChem ID | 56972194 |
| InChI Key | NIGHNKWLMSRCOZ-UHFFFAOYSA-N |
| Smiles | Cl.C1CN=C(N1)C1=CC2=CC=CC=C2C=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 100 mM in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 233.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.28 mL | 21.39 mL | 42.79 mL |
| 5 mM | 0.86 mL | 4.28 mL | 8.56 mL |
| 10 mM | 0.43 mL | 2.14 mL | 4.28 mL |
| 50 mM | 0.09 mL | 0.43 mL | 0.86 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Hudson et al (1999) Novel selective compounds for the investigation of imidazoline receptors. Ann.N.Y.Acad.Sci. 881 81 PMID: 10415900
Lione et al (1997) BU226: A selective ligand for rat brain imidazoline I2 sites. Soc.Neurosci.Abstr. 23 695.28 PMID:
Keywords: BU 226 hydrochloride, supplier, Potent, selective, I2, ligands, Imidazoline, Receptors, BU226, hydrochloride, I2, Receptors, I2, Receptors, Tocris Bioscience
