Biological Activity
Highly selective NPY Y1 receptor antagonist. Ki values are 25.7, 1420, 2403 and 7100 nM at Y1, Y2, Y4 and Y5 receptors respectively. Devoid of agonist activity at Y4 receptors.
Licensing Information
Sold under license
Technical Data
| M. Wt | 1221.46 |
| Formula | C58H92N16O13 |
| Sequence |
INPIYRLRY (Modifications: Tyr-9 = Tyr-OMe) |
| Storage | Desiccate at -20°C |
| CAS Number | 262418-00-8 |
| PubChem ID | 10820196 |
| InChI Key | JLQHEFJKMUJISI-QUCBMPEKSA-N |
| Smiles | [H]N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)OC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 1221.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.82 mL | 4.09 mL | 8.19 mL |
| 5 mM | 0.16 mL | 0.82 mL | 1.64 mL |
| 10 mM | 0.08 mL | 0.41 mL | 0.82 mL |
| 50 mM | 0.02 mL | 0.08 mL | 0.16 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Balasubramaniam et al (2001) Highly selective and potent neuropeptide Y (NPY) Y1 receptor antagonists based on [Pro30, Tyr32, Leu34]NPY(28-36)-NH2 (BW1911U90). J.Med.Chem. 44 1479 PMID: 11334558
Jois and Balasubramaniam (2003) Conformation of neuropeptide Y receptor antagonists: structural implications in receptor selectivity. Peptides 24 1035 PMID: 14499282
Jois et al (2006) Modeling of neuropeptide receptors Y1, Y4, Y5, and docking studies with neuropeptide antagonist. J.Biomol.Struct.Dyn. 23 497 PMID: 16494499
Keywords: BVD 10, supplier, selective, Y1, antagonists, devoid, Y4, agonists, activity, Neuropeptide, Y, Receptors, NPY, BVD10, neuropeptides, NPY, Receptors, NPY, Receptors, Tocris Bioscience
