Biological Activity
Non-competitive, cell-permeable inhibitor of protein tyrosine phosphatases (PTPs) (IC50 = 0.09 - 1.7 μM); displays irreversible inhibition through catalysis of the hydrogen peroxide-dependent oxidation of PTP. Enhances insulin signaling in vitro and insulin tolerance in ob/ob mice in vivo. Also inhibits several cytochrome P450 isoforms (IC50 <10 μM).
Compound Libraries
BVT 948 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 241.25 |
| Formula | C14H11NO3 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 39674-97-0 |
| PubChem ID | 6604934 |
| InChI Key | LLPBUXODFQZPFH-UHFFFAOYSA-N |
| Smiles | CC1(C)C(=O)N=C2C1=C(O)C(=O)C1=CC=CC=C21 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 12.06 | 50 | |
| ethanol | 12.06 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 241.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.15 mL | 20.73 mL | 41.45 mL |
| 5 mM | 0.83 mL | 4.15 mL | 8.29 mL |
| 10 mM | 0.41 mL | 2.07 mL | 4.15 mL |
| 50 mM | 0.08 mL | 0.41 mL | 0.83 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Liljebris et al (2004) Oxidation of protein tyrosine phosphatases as a pharmaceutical mechanism of action: a study using 4-hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione. J.Pharmacol.Exp.Ther. 309 711 PMID: 14747616
Keywords: BVT 948, supplier, Non-competitive, protein, tyrosine, phosphatase, inhibitors, inhibits, enhances, insulin, signaling, PTP, Shp1, Shp2, Protein, Tyrosine, Phosphatases, BVT948, Protein, Tyrosine, Phosphatases, Protein, Tyrosine, Phosphatases, Tocris Bioscience
