Biological Activity
Potent, selective inhibitor of 5-lipoxygenase. Long half-life and high oral bioavailability in vivo.
Technical Data
| M. Wt | 316.33 |
| Formula | C17H17FN2O3 |
| Storage | Desiccate at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 134470-38-5 |
| PubChem ID | 5353454 |
| InChI Key | UAIYNMRLUHHRMF-AATRIKPKSA-N |
| Smiles | CC(C=CC1=CC(OC2=CC=C(F)C=C2)=CC=C1)N(O)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 3 mM in ethanol and to 3 mM in DMSO |
Preparing Stock Solutions
The following data is based on the product molecular weight 316.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.16 mL | 15.81 mL | 31.61 mL |
| 5 mM | 0.63 mL | 3.16 mL | 6.32 mL |
| 10 mM | 0.32 mL | 1.58 mL | 3.16 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.63 mL |
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References
References are publications that support the products' biological activity.
Payne et al (1991) Hydroxamic acids and hydroxyureas as novel, selective 5-lipoxygenase inhibitors for possible use in asthma. Agents Actions Suppl. 34 189 PMID: 1793063
Salmon et al (1990) Inhibition of 5-lipoxygenase: development of hydroxamic acids and hydroxyureas as potential therapeutic agents. Adv.Prost.Throm.Leuk.Res. 21 109 PMID: 1847758
Yeadon et al (1993) Effect of BW B70C, a novel inhibitor of arachidonic acid 5-lipoxygenase, on allergen-induced bronchoconstriction and late-phase lung eosinophil accumulation in sensitised guinea-pigs. Agents Actions 38 8 PMID: 8480540
Keywords: BW-B 70C, supplier, 5-lipoxygenase, inhibitors, oxygenases, inhibits, oxidases, BWB70C, 5-LOX, Lipoxygenase, Lipoxygenase, Tocris Bioscience
