Biological Activity
Selective GABAB receptor agonist. Skeletal muscle relaxant. (R)-Baclofen (Cat. No. 0796) also available.
Technical Data
| M. Wt | 213.66 |
| Formula | C10H12ClNO2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1134-47-0 |
| PubChem ID | 2284 |
| InChI Key | KPYSYYIEGFHWSV-UHFFFAOYSA-N |
| Smiles | OC(CC(CN)C1=CC=C(Cl)C=C1)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 100 mM in 1eq. NaOH |
Preparing Stock Solutions
The following data is based on the product molecular weight 213.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.68 mL | 23.4 mL | 46.8 mL |
| 5 mM | 0.94 mL | 4.68 mL | 9.36 mL |
| 10 mM | 0.47 mL | 2.34 mL | 4.68 mL |
| 50 mM | 0.09 mL | 0.47 mL | 0.94 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Berthelot et al (1991) 3-Thienylaminobutyric acid and 3-furylaminobutyric acids - synthesis and GABAB receptor binding studies. J.Med.Chem. 34 2557 PMID: 1652022
Bowery et al (1993) GABAB receptor pharmacology. Annu.Rev.Pharmacol.Toxicol. 33 109 PMID: 8388192
Hill et al (1981) 3H-Baclofen and 3H-GABA bind to bicuculline-insensitive GABAB sites in rat brain. Nature 290 149 PMID: 6259535
Keywords: (RS)-Baclofen, supplier, Selective, GABAB, agonists, Receptors, GABAB, Receptors, GABAB, Receptors, Tocris Bioscience
