BiologicalActivity
Potentselectiveestrogenreceptormodulator(SERM)(IC50valuesare26and99nMforERαandERβrespectively).Inhibits17β-estrADIol-inducedproliferationinMCF-7cells.Co-treatmentwithRaloxifene(CatNo.2280)completelyabolishesraloxifene-inducedstimulationofluminalepithelialcellsandmyometrium.
LicensingInformation
SoldforresearchpurposesunderagreementfromPfizerInc.
CompoundLibraries
BazedoxifeneacetateisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 530.65 |
| Formula | C30H34N2O3.C2H4O2 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 198481-33-3 |
| PubChemID | 154256 |
| InChIKey | OMZAMQFQZMUNTP-UHFFFAOYSA-N |
| Smiles | CC2=C(C3=CC=C(O)C=C3)N(CC4=CC=C(OCCN5CCCCCC5)C=C4)C1=CC=C(O)C=C12.OC(C)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 53.06 | 100 | |
| ethanol | 10.61 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight530.65.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.88mL | 9.42mL | 18.84mL |
| 5mM | 0.38mL | 1.88mL | 3.77mL |
| 10mM | 0.19mL | 0.94mL | 1.88mL |
| 50mM | 0.04mL | 0.19mL | 0.38mL |
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ProductDatasheets
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