Tocris/Begacestat/4283/10/10毫克-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/Begacestat/4283/10/10毫克

Tocris/Begacestat/4283/10/10毫克

商品编号： 4283/10

品牌： Tocris Bioscience

市场价： ¥3780.00

美元价： 2268.00

产地：美国(厂家直采)

公司：

产品分类：蛋白酶类

公司分类： protease

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

立即询价

商品介绍

Description:γ-secretaseinhibitor;lowersAβ40andAβ42levels

AlternativeNames:GSI-953

ChemicalName:5-Chloro-N-[(1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2-(trifluoromethyl)propyl]-2-thiophenesulfonamide

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

γ-secretaseinhibitor;selectivelyinhibitscleavageofamyloidprecursorprotein(APP)overNotch.LowerslevelsofAβ42andAβ40(EC₅₀valuesare12.4and14.8nMrespectivelyincellsexpressinghumanrecombinantAPP).Orallyactive.

LicensingInformation

SoldforresearchpurposesunderagreementfromPfizerInc.

CompoundLibraries

BegacestatisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	391.74
Formula	C₉H₈ClF₆NO₃S₂
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	769169-27-9
PubChemID	11269353
InChIKey	PSXOKXJMVRSARX-SCSAIBSYSA-N
Smiles	ClC1=CC=C(S(N[C@H](CO)C(C(F)(F)F)C(F)(F)F)(=O)=O)S1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	39.17	100
	ethanol	39.17	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight391.74.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.55mL	12.76mL	25.53mL
5mM	0.51mL	2.55mL	5.11mL
10mM	0.26mL	1.28mL	2.55mL
50mM	0.05mL	0.26mL	0.51mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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