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当前位置: 首页 > 产品中心 > protease > Tocris/Begacestat/4283/10/10毫克
商品详细Tocris/Begacestat/4283/10/10毫克
Tocris/Begacestat/4283/10/10毫克
Tocris/Begacestat/4283/10/10毫克
商品编号: 4283/10
品牌: Tocris Bioscience
市场价: ¥3780.00
美元价: 2268.00
产地: 美国(厂家直采)
公司:
产品分类: 蛋白酶类
公司分类: protease
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description:γ-secretaseinhibitor;lowersAβ40andAβ42levels
AlternativeNames:GSI-953
ChemicalName:5-Chloro-N-[(1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2-(trifluoromethyl)propyl]-2-thiophenesulfonamide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

γ-secretaseinhibitor;selectivelyinhibitscleavageofamyloidprecursorprotein(APP)overNotch.LowerslevelsofAβ42andAβ40(EC50valuesare12.4and14.8nMrespectivelyincellsexpressinghumanrecombinantAPP).Orallyactive.

LicensingInformation

SoldforresearchpurposesunderagreementfromPfizerInc.

CompoundLibraries

BegacestatisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt391.74
FormulaC9H8ClF6NO3S2
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber769169-27-9
PubChemID11269353
InChIKeyPSXOKXJMVRSARX-SCSAIBSYSA-N
SmilesClC1=CC=C(S(N[C@H](CO)C(C(F)(F)F)C(F)(F)F)(=O)=O)S1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO39.17100
ethanol39.17100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight391.74.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.55mL12.76mL25.53mL
5mM0.51mL2.55mL5.11mL
10mM0.26mL1.28mL2.55mL
50mM0.05mL0.26mL0.51mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet