Biological Activity
Potent IP receptor agonist; analog of Epoprostenol (Cat. No. 2989). Potently inhibits ADP-induced platelet aggregation and P-selectin expression in vitro (pIC50 values are 8.26 and 8.56, respectively). Also increases vasodilation and reduces pulmonary hypertension in vivo. Orally active.
Technical Data
| M. Wt | 420.47 |
| Formula | C24H29NaO5 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 88475-69-8 |
| PubChem ID | 23663404 |
| InChI Key | YTCZZXIRLARSET-VJRSQJMHSA-M |
| Smiles | O[C@@H]1C[C@H]2[C@H]([C@@](C=CC=C3CCCC(O[Na])=O)=C3O2)[C@H]1/C=C/[C@@H](O)C(C)CC#CC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 10.51 | 25 |
Preparing Stock Solutions
The following data is based on the product molecular weight 420.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.38 mL | 11.89 mL | 23.78 mL |
| 5 mM | 0.48 mL | 2.38 mL | 4.76 mL |
| 10 mM | 0.24 mL | 1.19 mL | 2.38 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
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References
References are publications that support the products' biological activity.
Miyamoto et al (2003) Effects of TRA-418, a novel TP-receptor antagonist, and IP-receptor agonist, on human platelet activation and aggregation. Br.J.Pharmacol. 140 889 PMID: 14504133
Saito et al (1995) Effects of beraprost sodium (a PGI2 derivative) on chronic hypoxic pulmonary hypertension in the rat. Nihon Kyobu Shikkan Gakkai Zasshi. 33 497 PMID: 7609334
Keywords: Beraprost sodium, supplier, Prostacyclin, IP, receptor, agonists, pulmonary, hypertension, vasodilation, platelet, aggregation, Prostanoid, Receptors, Prostanoid, Receptors, Tocris Bioscience
