Biological Activity
Methobromide salt of (+)-bicuculline (Cat. No. 0130). Water soluble and more stable than bicuculline. Non-GABA receptor-mediated actions reported.
Technical Data
| M. Wt | 462.3 |
| Formula | C21H20BrNO6 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 73604-30-5 |
| PubChem ID | 6852386 |
| InChI Key | BWXCECYGGMGBHD-GRTNUQQKSA-M |
| Smiles | [H][C@](C(C=CC6=C5OCO6)=C5C(O4)=O)4[C@]2([H])C1=CC3=C(OCO3)C=C1CC[N+](C)2C.[Br-] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| phosphate buffered saline | 46.23 | 100 | |
| water | 23.11 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 462.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.16 mL | 10.82 mL | 21.63 mL |
| 5 mM | 0.43 mL | 2.16 mL | 4.33 mL |
| 10 mM | 0.22 mL | 1.08 mL | 2.16 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.43 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Bowery et al (1983) Characteristics of GABAB receptor binding sites on rat whole brain synaptic membranes. Br.J.Pharmacol. 78 191 PMID: 6297646
Seutin and Johnson (1999) Recent advances in the pharmacology of quaternary salts of bicuculline. TiPS 20 268 PMID: 10390643
Sperber et al (1987) Nigral infusions of muscimol or bicuculline facilitate seizures in developing rats. Brain Res. 465 243 PMID: 3440204
Keywords: (-)-Bicuculline methobromide, supplier, Water-soluble, GABAA, antagonists, Receptors, GABAA, Receptors, GABAA, Receptors, Tocris Bioscience
