Biological Activity
Methochloride salt of (+)-bicuculline (Cat. No. 0130). Water soluble and more stable than bicuculline. Non-GABA receptor-mediated actions reported.
Technical Data
| M. Wt | 417.85 |
| Formula | C21H20ClNO6 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 53552-05-9 |
| PubChem ID | 10047593 |
| InChI Key | RLJKFAMYSYWMND-GRTNUQQKSA-M |
| Smiles | [H][C@](C(C=CC6=C5OCO6)=C5C(O4)=O)4[C@]2([H])C1=CC3=C(OCO3)C=C1CC[N+](C)2C.[Cl-] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| phosphate buffered saline | 41.78 | 100 | |
| water | 41.78 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 417.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.39 mL | 11.97 mL | 23.93 mL |
| 5 mM | 0.48 mL | 2.39 mL | 4.79 mL |
| 10 mM | 0.24 mL | 1.2 mL | 2.39 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Kemp et al (1986) Quantitative evaluation of the potencies of GABA-receptor agonists and antagonists using the rat hippocampal slice preparation. Br.J.Pharmacol. 87 677 PMID: 3011168
Seutin et al (1997) Evidence for a non-GABAergic action of quaternary salts of bicuculline on dopaminergic neurones. Neuropharmacology 36 1653 PMID: 9517436
Seutin and Johnson (1999) Recent advances in the pharmacology of quaternary salts of bicuculline. TiPS 20 268 PMID: 10390643
Keywords: (-)-Bicuculline methochloride, supplier, Water-soluble, GABAA, antagonists, Receptors, GABAA, Receptors, GABAA, Receptors, Tocris Bioscience
