Biological Activity
Classical GABAA antagonist. Methoiodide salt (Cat. No. 2503), Methobromide salt (Cat. No. 0109) and Methochloride salt (Cat. No. 0131) also available.
Technical Data
| M. Wt | 367.36 |
| Formula | C20H17NO6 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 485-49-4 |
| PubChem ID | 10237 |
| InChI Key | IYGYMKDQCDOMRE-ZWKOTPCHSA-N |
| Smiles | [H][C@](C(C=CC6=C5OCO6)=C5C(O4)=O)4[C@]2([H])C1=CC3=C(OCO3)C=C1CCN2C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.74 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 367.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.72 mL | 13.61 mL | 27.22 mL |
| 5 mM | 0.54 mL | 2.72 mL | 5.44 mL |
| 10 mM | 0.27 mL | 1.36 mL | 2.72 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.54 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Curtis et al (1970) GABA, bicuculline and central inhibition. Nature 226 1222 PMID: 4393081
Olsen et al (1976) Studies on the neuropharmacological activity of bicuculline and related compounds. Brain Res. 102 283 PMID: 1247886
Piredda et al (1985) Intracerebral site of convulsant action of bicuculline. Life Sci. 36 1295 PMID: 3982215
Sieghart et al (1989) Multiplicity of GABAA-benzodiazepine receptors. TiPS 10 407 PMID: 2559519
Merck Index 12 1250 PMID:
Keywords: (+)-Bicuculline, supplier, Potent, GABAA, antagonists, Receptors, GABAA, Receptors, GABAA, Receptors, Tocris Bioscience
