![Tocris/[D-Phe12]-蛙皮素/1913/1/1毫克](https://www.ebiomall.cn/images/201712/1512521756115821138.jpg)
Biological Activity
Bombesin receptor antagonist; inhibits bombesin-induced amylase release in guinea pig pancreas (IC50 = 4 mM). Centrally active in vivo.
Technical Data
| M. Wt | 1629.9 |
| Formula | C74H112N22O18S |
| Sequence |
XQRLGNQWAVGFLM (Modifications: X = Glp, Phe-12 = D-Phe, Gly-14 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 108437-87-2 |
| PubChem ID | 57340149 |
| InChI Key | NXZVGUQLNAVPLJ-VKXSZNMLSA-N |
| Smiles | [H]N1[C@@H](CCC1=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 1629.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.61 mL | 3.07 mL | 6.14 mL |
| 5 mM | 0.12 mL | 0.61 mL | 1.23 mL |
| 10 mM | 0.06 mL | 0.31 mL | 0.61 mL |
| 50 mM | 0.01 mL | 0.06 mL | 0.12 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Heinz-Erian et al (1987) [D-Phe12]Bombesin analogues: a new class of bombesin receptor antagonists. Am.J.Physiol. 252 G439 PMID: 2435173
Merali et al (1988) (D-Phe12) Bombesin and substance P analogues function as central bombesin receptor antagonists. Synapse 2 282 PMID: 2463692
Moody et al (1988) Localization of receptors for bombesin-like peptides in the rat brain. Ann.N.Y.Acad.Sci. 547 114 PMID: 2853589
Keywords: [D-Phe12]-Bombesin, supplier, Bombesin, receptor, antagonists, GRP-Preferring, Receptors, BB1-3, Gastrin-Releasing, Peptide-Preferring, NMB-Preferring, Neuromedin, B-Preferring, Bombesin, Receptors, Bombesin, Receptors, Tocris Bioscience
