Biological Activity
Potent bradykinin receptor agonist. Highly selective for mammalian arterial smooth muscle bradykinin receptors, displaying ~ 50-fold greater potency than bradykinin. Elicits dose-dependent contractile effects in smooth muscle of guinea pig ileum (EC50 = 4.0 nM).
Technical Data
| M. Wt | 2179.55 |
| Formula | C100H159N31O24 |
| Sequence | DLPKINRKGPRPPGFSPFR |
| Storage | Desiccate at -20°C |
| CAS Number | 509151-65-9 |
| PubChem ID | 90473828 |
| InChI Key | ZEEWOWMYALYVCG-UOGIEMGNSA-N |
| Smiles | [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 2179.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.46 mL | 2.29 mL | 4.59 mL |
| 5 mM | 0.09 mL | 0.46 mL | 0.92 mL |
| 10 mM | 0.05 mL | 0.23 mL | 0.46 mL |
| 50 mM | 0.01 mL | 0.05 mL | 0.09 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Lai et al (2001) A novel bradykinin-related peptide from skin secretions of toad Bombina maxima and its precursor containing six identicals copies of the final product. Biochem.Biophys.Res.Comm. 286 259 PMID:
O'Rourke et al (2004) The smooth muscle pharmacology of maximakinin, a receptor-selective, bradykinin-related nonadecapeptide from the venom of the Chinese toad, Bombina maxima. Regul.Peptides 121 65 PMID:
Lee et al (2005) Cloning of bradykinin precursor cDNAs from skin of Bombina maxima reveals novel bombinakinin M antagonists and a bradykinin potential peptide. Regul.Peptides 127 207 PMID:
Keywords: Bombinakinin M, supplier, Potent, bradykinin, receptor, agonists, B1, B2, Receptors, Bradykinin, BombinakininM, Maximakinin, Bradykinin, Receptors, Bradykinin, Receptors, Tocris Bioscience
