BiologicalActivity
DualinhibitorofAblandSrckinases(IC50=1.2nMforSrcinanenzymaticassay).Displaysantiproliferativeactivityagainstchronicmyelogenousleukemia(CML)cellsanddecreasesthemotilityandinvasionofbreastcancercelllines.Alsoexhibitspotentantiproliferativeactivityinanchorage-independent,Src-transformedratfibroblasts(IC50=100nM).DisplaysselectivityforSrcovernon-Srcfamilykinasessuchasgrowthfactorreceptortyrosinekinases.
LicensingInformation
SoldforresearchpurposesunderagreementfromPfizerInc.
CompoundLibraries
BosutinibisalsoofferedaspartoftheTocriscreenPlus,TocriscreenKinaseInhibitorToolboxIIandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 530.45 |
| Formula | C26H29Cl2N5O3 |
| Storage | Storeat+4°C |
| Purity | ≥99% |
| CASNumber | 380843-75-4 |
| PubChemID | 5328940 |
| InChIKey | UBPYILGKFZZVDX-UHFFFAOYSA-N |
| Smiles | ClC1=CC(Cl)=C(OC)C=C1NC3=C(C#N)C=NC2=CC(OCCCN4CCN(C)CC4)=C(OC)C=C23 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 53.05 | 100 | |
| ethanol | 13.26 | 25 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight530.45.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.89mL | 9.43mL | 18.85mL |
| 5mM | 0.38mL | 1.89mL | 3.77mL |
| 10mM | 0.19mL | 0.94mL | 1.89mL |
| 50mM | 0.04mL | 0.19mL | 0.38mL |
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ProductDatasheets
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