![Tocris/[Phe8&936(CH-NH）-精氨酸9]-缓激肽/3229/1/1毫克](https://www.ebiomall.cn/images/201712/1512521756115821138.jpg)
Biological Activity
Selective bradykinin B2 receptor agonist that is resistant to carboxypeptidase cleavage. 5-fold more potent and exhibits a more prolonged duration of action than bradykinin (Cat No. 3004) in vivo.
Technical Data
| M. Wt | 1046.23 |
| Formula | C50H75N15O10 |
| Sequence |
RPPGFSPFR (Modifications: Phe-8 - Arg-9 peptide bond replaced with Ψ-(CH2-NH)) |
| Storage | Desiccate at -20°C |
| CAS Number | 118122-39-7 |
| PubChem ID | 3082903 |
| InChI Key | XKJBISGEHGXKBF-TZPCGENMSA-N |
| Smiles | [H]N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@H](CN[C@@H](CCCNC(N)=N)C(O)=O)CC1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 1046.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.96 mL | 4.78 mL | 9.56 mL |
| 5 mM | 0.19 mL | 0.96 mL | 1.91 mL |
| 10 mM | 0.1 mL | 0.48 mL | 0.96 mL |
| 50 mM | 0.02 mL | 0.1 mL | 0.19 mL |
Molarity Calculator
Reconstitution Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Drapeau et al (1988) [Phe8Ψ(CH2-NH)Arg9]bradykinin, a B2 receptor selective agonist which is not broken down by either kininase I or kininase II. Eur.J.Pharmacol. 155 193 PMID: 2907489
Marceau et al (2002) Kinin receptors: functional aspects. Int.Immunopharmacol. 2 1729 PMID: 12489786
Leeb-Lundberg et al (2005) International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol.Rev. 57 27 PMID: 15734727
Keywords: [Phe8Y(CH-NH)Arg9]-Bradykinin, supplier, Selective, B2, agonists, Bradykinin, Receptors, [Phe8psi(CH-NH)Arg9]-Bradykinin, Bradykinin, Receptors, Bradykinin, Receptors, Tocris Bioscience
