BiologicalActivity
Broadspectrumbromodomaininhibitor.AcceleratesFRAPrecoveryofBRD4andCREBBPincellsataconcentrationof1μM.
LicensingInformation
ThiscompoundissuppliedinconjunctionwiththeStructuralGenomicsConsortium.Forfurthercharacterizationdetails,pleasevisittheBromosporineprobesummaryontheSGCwebsite.
CompoundLibraries
BromosporineisalsoofferedaspartoftheTocriscreenPlusandTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 404.44 |
| Formula | C17H20N6O4S |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1619994-69-2 |
| PubChemID | 72943187 |
| InChIKey | UYBRROMMFMPJAN-UHFFFAOYSA-N |
| Smiles | CC1=C(NS(=O)(C)=O)C=C(C3=NN2C(C(NC(OCC)=O)=C3)=NN=C2C)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.44 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight404.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.47mL | 12.36mL | 24.73mL |
| 5mM | 0.49mL | 2.47mL | 4.95mL |
| 10mM | 0.25mL | 1.24mL | 2.47mL |
| 50mM | 0.05mL | 0.25mL | 0.49mL |
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ProductDatasheets
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