BiologicalActivity
Non-selectiveinhibitorofdopamineandnoradrenalintransporters(Kivaluesare1.4,2.8and45μMforNET,DATandSERTtransportersrespectively).Alsoinhibitsneuronalnicotinicacetylcholinereceptors.Displaysantidepressantactivityandaugmentsnicotineself-admiNISTrationatlowdosesinvivo.
CompoundLibraries
BupropionhydrochlorideisalsoofferedaspartoftheTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 276.2 |
| Formula | C13H18ClNO.HCl |
| Storage | DesiccateatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 31677-93-7 |
| PubChemID | 62884 |
| InChIKey | HEYVINCGKDONRU-UHFFFAOYSA-N |
| Smiles | ClC1=CC=CC(C(C(C)NC(C)(C)C)=O)=C1.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.62 | 100 | |
| ethanol | 27.62 | 100 | |
| water | 27.62 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight276.2.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.62mL | 18.1mL | 36.21mL |
| 5mM | 0.72mL | 3.62mL | 7.24mL |
| 10mM | 0.36mL | 1.81mL | 3.62mL |
| 50mM | 0.07mL | 0.36mL | 0.72mL |
MolarityCalculator
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ProductDatasheets
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