Biological Activity
Inhibitor of TCF-dependent transcription. Blocks BIO-induced β-catenin stabilization; reduces nuclear and cytosolic β-catenin levels in mouse L-cells. Inhibits growth and reduces TCF-dependent transcription in SW480 colon carcinoma cells.
Compound Libraries
CCT 031374 hydrobromide is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 434.33 |
| Formula | C23H19N3O.HBr |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1219184-91-4 |
| PubChem ID | 18554738 |
| InChI Key | MPILENOYNNNGKO-UHFFFAOYSA-N |
| Smiles | O=C(C4=CC=C(C5=CC=CC=C5)C=C4)CN1C3=C(C=CC=C3)N2C1=NCC2.Br |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 21.72 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 434.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.3 mL | 11.51 mL | 23.02 mL |
| 5 mM | 0.46 mL | 2.3 mL | 4.6 mL |
| 10 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
Molarity Calculator
Reconstitution Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Ewan et al (2010) A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription. Cancer Res. 70 5963 PMID: 20610623
Keywords: CCT 031374 hydrobromide, supplier, CCT031374, hydrobromide, TCF, transcription, inhibitors, inhibits, beta-catenin, b-catenin, β-catenin, stabilization, Beta-catenin, Beta-catenin, Tocris Bioscience
