Biological Activity
Synthetic retinoid that is an RARγ-selective agonist. Displays RARγ-dependent and -independent effects on differentiation and apoptosis.
Compound Libraries
CD 437 is also offered as part of the Tocriscreen Plus and Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 398.5 |
| Formula | C27H26O3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 125316-60-1 |
| PubChem ID | 135411 |
| InChI Key | LDGIHZJOIQSHPB-UHFFFAOYSA-N |
| Smiles | OC(=O)C1=CC=C2C=C(C=CC2=C1)C1=CC=C(O)C(=C1)C12CC3CC(CC(C3)C1)C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.85 | 100 | |
| ethanol | 7.97 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 398.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.51 mL | 12.55 mL | 25.09 mL |
| 5 mM | 0.5 mL | 2.51 mL | 5.02 mL |
| 10 mM | 0.25 mL | 1.25 mL | 2.51 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.5 mL |
Molarity Calculator
Reconstitution Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Zhao and Spanjaard (2003) The apoptotic action of the retinoid CD437/AHPN: diverse effects, common basis. J.Biomed.Sci. 10 44 PMID: 12566985
Wang et al (2011) Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1. Proc.Natl.Acad.Sci U.S.A. 108 18283 PMID: 21990348
Keywords: CD 437, supplier, RARγ, RARgamma-selective, agonists, RAR, RAMBA, Retinoic, Acid, Receptors, peroxisome, proliferator-activating, CD437, AHPN, Retinoic, Acid, Receptors, Retinoic, Acid, Receptors, Tocris Bioscience
