BiologicalActivity
Brainpenetrant,selectivepositiveallostericmodulatoratthemGlu5receptor(EC50valuesare10and20nMforhumanandratreceptorsrespectively).Antipsychotic;reversesamphetamine-inducedlocomotoractivityandamphetamine-induceddeficitsinprepulseinhibitioninrats.
LicensingInformation
ManufacturedandsoldunderlicensefromMerck&Co.,Inc.forusesolelyforpreclinicalresearchpurposes(ie:notforadmiNISTrationtoorotheruseinhumans)
CompoundLibraries
CDPPBisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 364.4 |
| Formula | C23H16N4O |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 781652-57-1 |
| PubChemID | 11245456 |
| InChIKey | BKUIZWILNWHFHD-UHFFFAOYSA-N |
| Smiles | O=C(C4=CC(C#N)=CC=C4)NC1=CC(C3=CC=CC=C3)=NN1C2=CC=CC=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.33 | 75 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight364.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.74mL | 13.72mL | 27.44mL |
| 5mM | 0.55mL | 2.74mL | 5.49mL |
| 10mM | 0.27mL | 1.37mL | 2.74mL |
| 50mM | 0.05mL | 0.27mL | 0.55mL |
MolarityCalculator
ReconstitutionCalculator
DilutionCalculator
ProductDatasheets
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