Biological Activity
Novel, selective non-competitive AMPA antagonist. Highly potent, long-acting anticonvulsant.
Technical Data
| M. Wt | 311.34 |
| Formula | C17H17N3O3 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 178616-26-7 |
| PubChem ID | 4377504 |
| InChI Key | MJKADKZSYQWGLL-UHFFFAOYSA-N |
| Smiles | COC1=CC2=C(C=C1OC)C(=NNC(=O)C2)C1=CC=C(N)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.13 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 311.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.21 mL | 16.06 mL | 32.12 mL |
| 5 mM | 0.64 mL | 3.21 mL | 6.42 mL |
| 10 mM | 0.32 mL | 1.61 mL | 3.21 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.64 mL |
Molarity Calculator
Reconstitution Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Chimirri et al (1997) 1-Aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones: novel AMPA receptor antagonists. J.Med.Chem. 40 1258 PMID: 9111300
De Sarro et al (1999) Effects of some AMPA receptor antagonists on the development of tolerance in epilepsy-prone rats and in pentylenetetrazole kindled rats. Eur.J.Pharmacol. 368 149 PMID: 10193651
De Sarro et al (1999) Anticonvulsant activity and plasma level of 2,3-benzodiazepin-4-ones (CFMs) in genetically epilepsy-prone rats. Pharmacol.Biochem.Behav. 63 621 PMID: 10462191
Keywords: CFM-2, supplier, Non-competitive, AMPA, antagonists, Glutamate, Receptors, iGlur, Ionotropic, AMPA, Receptors, AMPA, Receptors, Tocris Bioscience
