Biological Activity
Potent, selective and competitive NMDA receptor antagonist (Ki = 35 nM). Anticonvulsive following oral administration in vivo.
Technical Data
| M. Wt | 209.14 |
| Formula | C6H12NO5P |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 127910-31-0 |
| PubChem ID | 5950212 |
| InChI Key | BDYHNCZIGYIOGJ-DUXPYHPUSA-N |
| Smiles | NC(C(O)=O)/C=C(C)/CP(O)(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 20.91 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 209.14. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.78 mL | 23.91 mL | 47.81 mL |
| 5 mM | 0.96 mL | 4.78 mL | 9.56 mL |
| 10 mM | 0.48 mL | 2.39 mL | 4.78 mL |
| 50 mM | 0.1 mL | 0.48 mL | 0.96 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Fagg et al (1990) CGP 37849 and CGP 39551: novel and potent competitive N-methyl-D-asparate receptor antagonists with oral activity. Br.J.Pharmacol. 99 791 PMID: 1972895
Loscher and Honack (1991) Anticonvulsant and behavioural effects of two novel competitive N-methyl-D-aspartic acid receptor antagonists, CGP 37849 and CGP 39551, in the kindling model of epilepsy. Comparison with MK-801 and carbamazepine. J.Pharmacol.Exp.Ther. 256 432 PMID: 1671593
Pozza et al (1990) Electrophysiological characterization of a novel potent and orally active NMDA receptor antagonist: CGP 37849 and its ethylester CGP 39551. Eur.J.Pharmacol. 182 91 PMID: 1976098
Keywords: CGP 37849, supplier, Potent, selective, NMDA, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic, CGP37849, NMDA, Receptors, NMDA, Receptors, Tocris Bioscience
