Biological Activity
Potent, selective and competitive NMDA antagonist (Ki = 310 nM for inhibition of [3H]-CPP binding in rat brain). Centrally active upon oral administration in vivo.
Technical Data
| M. Wt | 237.19 |
| Formula | C8H16NO5P |
| Storage | Desiccate at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 127910-32-1 |
| PubChem ID | 6372334 |
| InChI Key | OKDOWCKDTWNRCB-GQCTYLIASA-N |
| Smiles | NC(C(OCC)=O)/C=C(C)/CP(O)(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 2.37 | 10mM with gentle warming | |
| water | 23.72 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 237.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.22 mL | 21.08 mL | 42.16 mL |
| 5 mM | 0.84 mL | 4.22 mL | 8.43 mL |
| 10 mM | 0.42 mL | 2.11 mL | 4.22 mL |
| 50 mM | 0.08 mL | 0.42 mL | 0.84 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
D'Hooge et al (1999) Effects of competitive NMDA receptor antagonists on excitatory amino-acid-evoked currents in mouse spinal cord. Fundam.Clin.Pharmacol. 13 67 PMID: 10027090
Fagg et al (1990) CGP 37849 and CGP 39551: novel and potent competitive N-methyl-D-asparate receptor antagonists with oral activity. Br.J.Pharmacol. 99 791 PMID: 1972895
Loscher and Honack (1991) Anticonvulsant and behavioural effects of two novel competitive N-methyl-D-aspartic acid receptor antagonists, CGP 37849 and CGP 39551, in the kindling model of epilepsy. Comparison with MK-801 and carbamazepine. J.Pharmacol.Exp.Ther. 256 432 PMID: 1671593
Keywords: CGP 39551, supplier, Potent, selective, competitive, NMDA, antagonist, Glutamate, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic, CGP39551, NMDA, Receptors, NMDA, Receptors, Tocris Bioscience
