BiologicalActivity
Potent,selectiveGABABreceptorantagonist(IC50=5nM)thatpreventsagonistbinding(pKi=8.35)andinhibitsGABAandglutamaterelease(pEC50valuesare8.08and7.85respectively).InhibitsGABABresponsestobaclofen(IC50=130nMinanisoproterenolassay)andpotentiatesthehypoglycemicresponsetoglucoseinvitro.
LicensingInformation
SoldwiththepermissionofNovartisPharmaAG
CompoundLibraries
CGP55845hydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 438.71 |
| Formula | C18H22Cl2NO3P.HCl |
| Storage | StoreatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 149184-22-5 |
| PubChemID | 5311042 |
| InChIKey | ZODSPDOOCZZEIM-BBRMVZONSA-N |
| Smiles | Cl.C[C@H](NC[C@H](O)CP(O)(=O)CC1=CC=CC=C1)C1=CC=C(Cl)C(Cl)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.87 | 100mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight438.71.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.28mL | 11.4mL | 22.79mL |
| 5mM | 0.46mL | 2.28mL | 4.56mL |
| 10mM | 0.23mL | 1.14mL | 2.28mL |
| 50mM | 0.05mL | 0.23mL | 0.46mL |
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ProductDatasheets
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