Biological Activity
Endogenous neuropeptide; potent vasodilator which also exerts cardiovascular, pro-inflammatory and metabolic effects.
Technical Data
| M. Wt | 3807 |
| Formula | C162H262N50O52S2 |
| Sequence |
SCNTATCVTHRLAGLLSRSGGVVKDNFVPTNVGSEAF (Modifications: Disulfide bridge between 2 - 7, Phe-37 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 83651-90-5 |
| PubChem ID | 90479760 |
| InChI Key | SVAGNGUJZNLSEY-TYNJZYKVSA-N |
| Smiles | [H]N[C@@H](CO)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC1=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 0.80 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 3807. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.26 mL | 1.31 mL | 2.63 mL |
| 5 mM | 0.05 mL | 0.26 mL | 0.53 mL |
| 10 mM | 0.03 mL | 0.13 mL | 0.26 mL |
| 50 mM | 0.01 mL | 0.03 mL | 0.05 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Brain et al (1985) Calcitonin gene-related peptide is a potent vasodilator. Nature 313 54 PMID: 3917554
Morris et al (1984) Isolation and characterization of human calcitonin gene-related peptide. Nature 308 746 PMID: 6609312
Nakamura et al (1998) Calcitonin gene-related peptide as a GH secretagogue in human and rat pituitary somatotrophs. Brain Res. 807 203 PMID: 9757038
Poyner (1995) Pharmacology of receptors for calcitonin gene-related peptide and amylin. TiPS 16 424 PMID: 8578616
Salim et al (1998) Calcitonin gene-related peptide potentiates nicotinic acetylcholine receptor-operated slow Ca2+ mobilization at mouse muscle endplates. Br.J.Pharmacol. 125 277 PMID: 9786499
Keywords: CGRP (rat), supplier, Potent, vasodilator, CGRP, Receptors, calcitonin-gene, related, peptide, AMY1, AMY2, AMY3, agonists, Calcitonin, Gene-Related, Peptide, (rat), Calcitonin, and, Related, Receptors, Calcitonin, and, Related, Receptors, Tocris Bioscience
