Biological Activity
5-HT1B full agonist, 10-fold selective over 5-HT1A and 1000-fold selective over 5-HT2C receptors. Centrally active following systemic administration.
Technical Data
| M. Wt | 566.49 |
| Formula | C17H17F3N4.2C4H4O4 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 109028-10-6 |
| PubChem ID | 9915956 |
| InChI Key | HTEVMLYDEWVIQE-SPIKMXEPSA-N |
| Smiles | O=C(O)/C=CC(O)=O.O=C(O)/C=CC(O)=O.FC(C1=CC3=C(N2C=CC=C2C(N4CCN(CC4)C)=N3)C=C1)(F)F |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 22.66 | 40 | |
| water | 2.83 | 5 |
Preparing Stock Solutions
The following data is based on the product molecular weight 566.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.77 mL | 8.83 mL | 17.65 mL |
| 5 mM | 0.35 mL | 1.77 mL | 3.53 mL |
| 10 mM | 0.18 mL | 0.88 mL | 1.77 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.35 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Neale et al (1987) Biochemical and pharmacological characterization of CGS 12066B, a selective serotonin-1B agonist. Eur.J.Pharmacol. 136 1 PMID: 3496228
Schoeffter and Hoyer (1989) Interaction of arylpiperazines with 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptors: do discriminatory 5-HT1B receptor ligands exist? Naunyn Schmiedebergs Arch.Pharmacol. 339 675 PMID: 2770889
Tomkins and O'Neill (2000) Effect of 5-HT1B receptor ligands on self-administration of ethanol in an operant procedure in rats. Pharmacol.Biochem.Behav. 66 129 PMID: 10837852
Keywords: CGS 12066B dimaleate, supplier, 5-HT1B, agonists, Serotonin, Receptors, 5-HT1, CGS12066B, dimaleate, 5-HT1B, Receptors, 5-HT1B, Receptors, Tocris Bioscience
