Biological Activity
Potent somatostatin receptor 1 (sst1) agonist; displays selectivity for sst1 (IC50 values are 30.9 nM, 345 nM, > 1 μM, > 10 μM and > 10μM for human sst1, sst3, sst4, sst2 and sst5 respectively). Attenuates somatostatin release in the rat nucleus accumbens.
Licensing Information
Sold with the permission of the SALK Institute.
Technical Data
| M. Wt | 1485.8 |
| Formula | C74H96N14O15S2 |
| Sequence | CKFFWXTFTSC (Modifications: Cyclic Cys1-Cys11, X=4-[[(1-methylethyl)amino]methyl]-Phe) |
| Storage | Store at -20°C |
| CAS Number | 174688-78-9 |
| PubChem ID | 90488765 |
| InChI Key | LFOPEPKKBBIGHF-RXUBGYFDSA-N |
| Smiles | [H]N[C@H]1CSSC[C@H](NC[C@H](CO)NC(=O)[C@H](NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](NC(=O)[C@@H](CC2=CC=C(CNC(C)C)C=C2)NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](CCCCN)NC1=O)[C@@H](C)O)[C@@H](C)O)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 0.30 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 1485.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.67 mL | 3.37 mL | 6.73 mL |
| 5 mM | 0.13 mL | 0.67 mL | 1.35 mL |
| 10 mM | 0.07 mL | 0.34 mL | 0.67 mL |
| 50 mM | 0.01 mL | 0.07 mL | 0.13 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Chen et al (1999) Structural basis for the binding specificity of a SSTR1-selective analog of somatostatin. Biochem.Biophys.Res.Commun. 258 689 PMID: 10329447
Rivier et al (2001) Potent somatostatin undecapeptide agonists selective for somatostatin receptor 1 (sst1). J.Med.Chem. 44 2238 PMID: 11405660
Vasilaki et al (2004) The somatostatin receptor (sst1) modulates the release of somatostatin in the nucleus accumbens of the rat. Neuropharmacology 47 612 PMID: 15380378
Keywords: CH 275, supplier, CH275, supplier, somatostatin, receptor, 1, sst1, sstr1, agonists, potent, selective, nucleus, accumbens, Somatostatin, Receptors, Somatostatin, Receptors, Tocris Bioscience
