Biological Activity
A selective mGlu5 metabotropic glutamate receptor agonist, completely inactive at mGlu1a receptors expressed in CHO cells. Active in vivo. CHPG sodium salt (Cat. No. 3695) also available.
Technical Data
| M. Wt | 201.61 |
| Formula | C8H8NO3Cl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 170846-74-9 |
| PubChem ID | 3645780 |
| InChI Key | UNIDAFCQFPGYJJ-UHFFFAOYSA-N |
| Smiles | NC(C(O)=O)C1=CC(O)=CC=C1Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1.1eq. NaOH | 20.16 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 201.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.96 mL | 24.8 mL | 49.6 mL |
| 5 mM | 0.99 mL | 4.96 mL | 9.92 mL |
| 10 mM | 0.5 mL | 2.48 mL | 4.96 mL |
| 50 mM | 0.1 mL | 0.5 mL | 0.99 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Bao et al (2001) Selective mGluR5 receptor antagonist or agonist provides neuroprotection in a rat model of focal cerebral ischaemia. Brain Res. 922 173 PMID: 11743947
Doherty et al (1997) (RS)-2-Chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but not mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus. Neuropharmacology 36 265 PMID: 9144665
Salt et al (1999) Antagonism of the mGlu5 agonist 2-chloro-5-hydroxyphenylglycine by the novel selective mGlu5 antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) in the thalamus. Br.J.Pharmacol. 127 1057 PMID: 10455248
Ugolini et al (1999) Potentiation of NMDA and AMPA responses by the specific mGluR5 agonist CHPG in spinal cord motoneurones. Neuropharmacology 38 1569 PMID: 10530818
Keywords: CHPG, supplier, mGlu5, mGluR5, selective, agonist, mGlur, Group, I, Receptors, Glutamate, Metabotropic, Glutamate, (Metabotropic), Group, I, Receptors, Glutamate, (Metabotropic), Group, I, Receptors, Tocris Bioscience
