Biological Activity
Protein kinase D (PKD) inhibitor (IC50 values are 0.6, 0.7 and 3.2 μM for PKD2, PKD3 and PKD1 respectively). Cell permeable (EC50 = 10 μM for PKD1 inhibition). ATP-competitive.
Compound Libraries
CID 2011756 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 396.87 |
| Formula | C22H21ClN2O3 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 638156-11-3 |
| PubChem ID | 2011756 |
| InChI Key | XQJWTJLJEYIUDZ-UHFFFAOYSA-N |
| Smiles | O=C(NC3=CC=C(CN4CCOCC4)C=C3)C1=CC=C(C2=CC=CC(Cl)=C2)O1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 19.84 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 396.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.52 mL | 12.6 mL | 25.2 mL |
| 5 mM | 0.5 mL | 2.52 mL | 5.04 mL |
| 10 mM | 0.25 mL | 1.26 mL | 2.52 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.5 mL |
Molarity Calculator
Reconstitution Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Sharlow et al (2011) Discovery of diverse small molecule chemotypes with cell-based PKD1 inhibitory activity. PLoS One 6 e25134 PMID: 21998636
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