Biological Activity
Selective protein kinase D (PKD) inhibitor (IC50 values are 0.182, 0.280, 0.227, >10, 15.3, 20.3, 40.5 and >50 μM at PKD1, PKD2, PKD3, PKC, CAK, PLK1, CAMKIIα and Akt respectively). Blocks PKD-mediated protein transport and inhibits prostate cancer cell proliferation, migration and invasion in vitro.
Technical Data
| M. Wt | 217.22 |
| Formula | C12H11NO3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 521937-07-5 |
| PubChem ID | 755673 |
| InChI Key | AACFPJSJOWQNBN-UHFFFAOYSA-N |
| Smiles | OC1=CC2=C(OC3=C2CCCNC3=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 21.72 | 100 | |
| ethanol | 1.09 | 5mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 217.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.6 mL | 23.02 mL | 46.04 mL |
| 5 mM | 0.92 mL | 4.6 mL | 9.21 mL |
| 10 mM | 0.46 mL | 2.3 mL | 4.6 mL |
| 50 mM | 0.09 mL | 0.46 mL | 0.92 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Sharlow et al (2008) Potent and selective disruption of protein kinase D functionality by benzoxoloazepinolone. J.Biol.Chem. 283 33516 PMID: 18829454
Keywords: CID 755673, supplier, Selective, protein, kinases, D, inhibitors, inhibits, PKD, CID755673, Protein, Kinase, D, Protein, Kinase, D, Tocris Bioscience
