Biological Activity
Selective inhibitor of MMP-13 (89% inhibition at 10 μg/mL) that displays no activity at MMP-1, MMP-9 or TACE. Inhibits in vitro invasion by the human pituitary adenoma cell line HP75.
Technical Data
| M. Wt | 338.83 |
| Formula | C17H23N2O3.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1188890-36-9 |
| PubChem ID | 16760373 |
| InChI Key | PIOACXKZWXHBRB-UHFFFAOYSA-N |
| Smiles | Cl.O=C(NCCCCN1CCOCC1)C1=CC2=CC=CC=C2O1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 25.41 | 75 | |
| water | 33.88 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 338.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.95 mL | 14.76 mL | 29.51 mL |
| 5 mM | 0.59 mL | 2.95 mL | 5.9 mL |
| 10 mM | 0.3 mL | 1.48 mL | 2.95 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.59 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Chen et al (2000) Structure-based design of a novel, potent, and selective inhibitor for MMP-13 utilizing NMR spectroscopy and computer-aided molecular design. J.Am.Chem.Soc. 122 9648 PMID:
Borg et al (2003) IL1 alpha, IL6 and MMP13 are required for invasion by the human pituitary cell line HP75. Endocrine Abstr. 5 122 PMID:
Keywords: CL 82198 hydrochloride, supplier, Selective, inhibitors, inhibits, MMP-13, Matrixins, Matrix, Metalloproteinase, MMP, Metalloprotease, Proteinases, Proteases, CL82198, hydrochloride, Matrix, Metalloprotease, Matrix, Metalloprotease, Tocris Bioscience
