Biological Activity
Potent AMPA/kainate receptor antagonist. Also antagonist at glycine modulatory site on NMDA receptor complex. CNQX disodium salt (Cat. No. 1045) also available.
Technical Data
| M. Wt | 232.16 |
| Formula | C9H4N4O4 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 115066-14-3 |
| PubChem ID | 3721046 |
| InChI Key | RPXVIAFEQBNEAX-UHFFFAOYSA-N |
| Smiles | [O-][N+](=O)C1=C(C=C2NC(=O)C(=O)NC2=C1)C#N |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 23.22 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 232.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.31 mL | 21.54 mL | 43.07 mL |
| 5 mM | 0.86 mL | 4.31 mL | 8.61 mL |
| 10 mM | 0.43 mL | 2.15 mL | 4.31 mL |
| 50 mM | 0.09 mL | 0.43 mL | 0.86 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Honore et al (1988) Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists. Science 241 701 PMID: 2899909
King et al (1992) Antagonism of synaptic potentials in ventral horn neurones by 6-cyano-7-nitroquinoxaline-2,3-dione: a study in the rat spinal cord in vitro. Br.J.Pharmacol. 107 375 PMID: 1358390
Long et al (1990) Effect of 6-cyano-2,3-dihydroxy-7-nitro-quinoxaline (CNQX) on dorsal root-, NMDA-, kainate and quisqualate-mediated depolarization of rat motoneurones in vitro. Br.J.Pharmacol. 100 850 PMID: 1976402
Watkins et al (1990) Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists. TiPS 11 25 PMID: 2155495
Keywords: CNQX, supplier, Potent, AMPA/kainate, antagonists, NMDA, glycine, site, Glutamate, Kainate, Receptors, iGluR, Ionotropic, AMPA, N-Methyl-D-Aspartate, AMPA, Receptors, NMDA, Receptors, Kainate, Receptors, AMPA, Receptors, Tocris Bioscience
