BiologicalActivity
Apolipoprotein(ApoE)peptidefragmentthatfunctionsviathelow-densitylipoproteinreceptor-relatedprotein(LRP).Substantiallyreducesthesymptomsofexperimentalautoimmuneencephalomyelitis,amodelofhumanmultiplesclerosis,andsuppressesinflammation,demyelinationandinfiltrationofcellsintothespinalcord.Alsoactsasanon-competitiveantagoNISTatα7nicotinicacetylcholinereceptors(IC50=445nM).
TechnicalData
| M.Wt | 2169.73 |
| Formula | C97H181N37O19 |
| Sequence | LRVRLASHLRKLRKRLL (Modifications:Leu-1=N-terminalAc,Leu-17=C-terminalamide) |
| Storage | Storeat-20°C |
| CASNumber | 514200-66-9 |
| PubChemID | 16201427 |
| InChIKey | QTWXJKVJIKDSLC-KIZXDXQLSA-N |
| Smiles | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(C)=O)C(C)C)C(N)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solubility | Solubleto1mg/mlinwater |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight2169.73.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 0.46mL | 2.3mL | 4.61mL |
| 5mM | 0.09mL | 0.46mL | 0.92mL |
| 10mM | 0.05mL | 0.23mL | 0.46mL |
| 50mM | 0.01mL | 0.05mL | 0.09mL |
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