Biological Activity
Selective 5-HT1D receptor agonist. Produces dose-dependent decreases in extracellular 5-HT concentration.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Technical Data
| M. Wt | 351.4 |
| Formula | C19H21N5O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 151272-90-1 |
| PubChem ID | 5487088 |
| InChI Key | YPFIYPNOWVPAPR-OAHLLOKOSA-N |
| Smiles | CN(CCC4)[C@H]4CC1=CNC2=C1C=C(NC3=NC=CC=C3[N+]([O-])=O)C=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.14 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 351.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.85 mL | 14.23 mL | 28.46 mL |
| 5 mM | 0.57 mL | 2.85 mL | 5.69 mL |
| 10 mM | 0.28 mL | 1.42 mL | 2.85 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.57 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Hertel et al (1999) The antipsychotic drug risperidone interacts with auto- and hetero-receptors regulating serotonin output in the rat frontal cortex. Neuropharmacology 38 1175 PMID: 10462130
Mansbach et al (1996) CP-135,807, a selective 5-HT1D agonist: effects in drug discrimination and punishment procedures in the pigeon. Psychopharmacology 128 313 PMID: 8972551
Rollema et al (1996) Combined administration of a 5-hydroxytryptamine (5-HT)1D antagonist and a 5-HT reuptake inhibitor synergistically increases 5-HT release in guinea pig hypothalamus in vivo. J.Neurochem. 67 2204 PMID: 8863532
Keywords: CP 135807, supplier, selective, 5-HT, serotonin, 5-HT1D, receptors, agonists, Pfizer, CP135807, 5-HT1D, Receptors, 5-HT1D, Receptors, Tocris Bioscience
