Biological Activity
Broad spectrum MMP inhibitor (IC50 values are 0.7, 0.9, 13, 16 and 1170 nM for MMP-2, MMP-13, MMP-9, MMP-3 and MMP-1 respectively). Attenuates early left ventricular dilation after experimental myocardial infarction in mice.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Compound Libraries
CP 471474 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 368.38 |
| Formula | C16H17FN2O5S |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 210755-45-6 |
| PubChem ID | 9907286 |
| InChI Key | QCOQJYRPDUMCNP-UHFFFAOYSA-N |
| Smiles | FC1=CC=C(OC2=CC=C(S(NC(C)(C)C(NO)=O)(=O)=O)C=C2)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.84 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 368.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.71 mL | 13.57 mL | 27.15 mL |
| 5 mM | 0.54 mL | 2.71 mL | 5.43 mL |
| 10 mM | 0.27 mL | 1.36 mL | 2.71 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.54 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Rohde et al (1999) Matrix metalloproteinease inhibition attenuates early left ventricular enlargement after experimental myocardial infarction in mice. Circulation 99 3063 PMID: 10368126
Lindsey et al (2002) Selective matrix metalloproteinase inhibition reduces left ventricular remodeling but does not inhibit angiogenesis after myocardial infarction. Circulation 105 753 PMID: 11839633
Fang et al (2007) Differences in inflammation, MMP activation and collagen damage account for gender difference in murine cardiac rupture following myocardial infarction. J.Mol.Cell.Cardiol. 43 535 PMID: 17689559
Keywords: CP 471474, supplier, CP471474, MMP, matrix, metalloproteinase, metalloprotease, inhibitors, inhibits, broad, spectrum, proteinases, proteases, Pfizer, Matrix, Metalloprotease, Matrix, Metalloprotease, Tocris Bioscience
